Combinatorial library of novel benzenesulfonamides was docked (Schrodinger Glide) into mycobacterial carbonic anhydrase (mtCA II) and human (hCA II) Bartwachs / Bartbalsam isoforms with an aim to find drug candidates with selective activity on mtCA II.The predicted selectivity was calculated based on optimized MM-GBSA free energies for ligand enzym
The most powerful feature of the Monte Carlo method is the possibility of simulating all individual particle interactions in three dimensions and performing numerical experiments with a preset error.These facts were the motivation behind the development of a general-purpose Monte Carlo SRNA program for proton transport simulation in technical syste
The phenomenon of population at Kampung Sawah Jatimurni District of Pondok Melati Bekasi shows that its people are not from ethnic Batak, but most of them are Sundanese and Betawinese.In the kinship structure Polarized of society of both ethnics, the term clan is unfamiliar.Rather it is known in the community of North Sumatra namely Batak.This WIDE
BACKGROUND Because of the tendency towards equal parental rights in post-divorce custody decisions, the number of children living partially in two households after divorce has increased.Because of this evolution, traditional family typologies have been challenged.OBJECTIVE In this study, we want to describe the post-divorce custody arrangements and
CRISPR-based gene drives offer promising prospects for controlling disease-transmitting vectors and agricultural pests.A significant challenge for successful suppression-type drive is the rapid evolution of resistance alleles.One approach to mitigate the development of resistance involves targeting functionally constrained regions using multiple gR